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KMID : 0380020210360040221
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Korean Journal of Biotechnology and Bioengineering
2021 Volume.36 No. 4 p.221 ~ p.230
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Electropolymerized Molecularly Imprinted Polymers (EMIPs)-Based Electrochemical Sensor
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Cho Chae-Hwan
Kim Ji-Hong
Shin Jae-Hwan
Yang Hyo-Jung
Park Jong-Pil
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Abstract
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Biosensors have been widely studied and developed as a tool in various fields, including pharmaceutical, food safety, environmental and medical applications. Antibodybased immunosensors are considered as gold standard method, however, more advanced biosensor without need of antibody as receptor is needed. Molecularly imprinted polymers (MIPs) are synthetic receptors obtained by polymerization of functional monomers in the presence of the target molecule and can form high specific binding sites to the target molecules depending on shape, size, and functionality. One of the most synthesis of MIPs is electropolymerization that use electrochemical method. This method can easily manipulate the desired morphology and thickness of the polymer films. Various EMIPs (electropolymerized molecular imprinted polymers) based biosensors have been developed for detection of small molecule such as chemicals, drugs, and toxins. In this review, we summarize the synthetic methods and characteristics of EMIPs-based biosensor for various targets.
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KEYWORD
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electropolymerization, molecular imprinted polymers, electrochemical biosensor, protein detection
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